On behalf of Cure Mito Foundation, we completed high-throughput drug screens and dose response studies in yeast. Next up: validating hits in SURF1 patient fibroblasts and Complex IV yeast avatars.
This is fascinating! Is this 10k+ chemical library available to license or is it a proprietary toolset?
Thanks again for these regular updates on your screening. I enjoy being kept up to date on the developments rather than all together in a final research paper. The sensitisers are an interesting set of compounds worthy of further research. Do you think the rescuers found in both the SURF1 and PGAP3 point to more general survival or growth mechanisms than gene specific rescue? Keep up this wonderful project